Race-Neutral Kidney Tests Boost Chance Of Black Candidates Getting Life Saving Transplant

In the United States, Black people are four times as likely to develop kidney failure as pink people, but they are much less likely to receive a lifesaving kidney transplant.
A new test hopes to eliminate this racial disparity.

Five years ago, Arlette Ebanks experienced severe kidney pain that she believed suggested a criminal need for a transplant. Her doctors disagreed, but the 52-year-old Northeast D.C. resident and mother of two, who worked for the Department of Transportation for more than half of her life until her deteriorating health landed her on permanent disability, had grown ever more anxious as healthcare providers attempted various measures of maintenance.

Recently, physicians at George Washington University Hospital told Ebanks that she should have been on the transplant list, and understandably, Ebanks wondered why previous doctors hadn’t done so.  Now, Ebanks knows why. She equates all the time she spent stressing and worrying this caused due to her race.

Once widely used test proved to be problematic as it overestimated how well Black people’s kidneys were functioning, making them look healthier than they really were. An automated formula calculated results for Black and non-Black patients that were far different from those of others, delaying organ failure diagnosis and, ultimately, proper evaluation for a kidney transplant.

The disparity only exacerbated existing inequities, with Black patients being more susceptible to needing a new kidney but less likely to receive one. She states that it is infuriating how much racism is seen in medicine, bias in healthcare that is causing unnecessary pain and suffering among African Americans.

The U.S. organ transplant network has now ordered hospitals and care facilities to use race-neutral test results only when adding new patients to the kidney transplant waiting list. Further, the National Kidney Foundation and the American Society of Nephrology told laboratories to transition to race-neutral equations when calculating kidney function. 

The policy shift has led to adjustments for more than 14,000 Black kidney transplant candidates, crediting them with lost waiting time and elevating their priority for transplantation. Between January 2023 and mid-March 2024, over 14,300 Black candidates had their wait times recalibrated, resulting in more than 2,800 successful transplants, including Ebanks.

As the director of Health Equity, Anti-Racism, and Community Engagement at Penn Medicine, Dr. Eneanya spearheads internal initiatives to promote diversity and inclusion within the Renal Electrolyte and Hypertension Division. Additionally, she is actively involved in community outreach programs to address racial disparities in kidney disease awareness and screening.

Not everyone approaches medicine with a health equity lens. Many clinicians are not aware of existing disparities — how Black patients do not get referred to nephrology as early as white patients and do not have sufficient access to transplant procedures. In medicine, the tendency is to say, ‘This is what a study showed, so this is what we should do, focusing on biomarkers and statistical tests without examining issues of ethics or health equity.

Dr. Eneanya noted that the revelation of racial bias within the kidney transplantation system underscores the pressing need for reformative measures to ensure equitable healthcare access for all individuals, regardless of race or ethnicity.

Screening patients estimated glomerular filtration rates (eGFR) generally help physicians determine how well the kidneys are filtering and Eneanya is working to ensure that the test accounts for all people. “I sit on a joint American Society of Nephrology-National Kidney Foundation task force that is revising formal reporting guidelines to exclude racial bias,” Dr. Eneanya stated. Many physicians across the country, including some at Penn, have stopped using the race multiplier already. And while the eGFR is a frontline test for kidney function, there are other tests that don’t incorporate race. When there is any doubt about the accuracy of an eGFR score, other confirmatory tests that do not use race should be performed.

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